BIOMAT Database Logo BIOMAT Database Logo

[Search for translocation heterozygous female mice among the progeny from males subjected to chemical mutagen (thioTHEPA) exposure]. 1977

Kh Kh Semenov, and A M Malashenko

C57Bl/6Y male mice were intraperitoneally injected with thioTEPA at a dose of 1.25 mg/kg. The male mice were crossed with F1CD hybrid females during the second week after the treatment. 122 females F1 obtained from this cross were examined. The embryonic lethality was studied and preparations of meiotic metaphases I in oocytes were found among the progeny F1. Among F1 females 41 (33.6%) "semisterile" and sterile ones were found. Translocations were cytogenetically confirmed only in 8 females out of 38 investigated.

UI MeSH Term Description Entries
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D008811 Mice, Inbred DBA An inbred strain of mouse. Specific substrains are used in a variety of areas of BIOMEDICAL RESEARCH such as DBA/1J, which is used as a model for RHEUMATOID ARTHRITIS. Mice, DBA,Mouse, DBA,Mouse, Inbred DBA,DBA Mice,DBA Mice, Inbred,DBA Mouse,DBA Mouse, Inbred,Inbred DBA Mice,Inbred DBA Mouse
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D009865 Oocytes Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM). Ovocytes,Oocyte,Ovocyte
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002869 Chromosome Aberrations Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS. Autosome Abnormalities,Cytogenetic Aberrations,Abnormalities, Autosome,Abnormalities, Chromosomal,Abnormalities, Chromosome,Chromosomal Aberrations,Chromosome Abnormalities,Cytogenetic Abnormalities,Aberration, Chromosomal,Aberration, Chromosome,Aberration, Cytogenetic,Aberrations, Chromosomal,Aberrations, Chromosome,Aberrations, Cytogenetic,Abnormalities, Cytogenetic,Abnormality, Autosome,Abnormality, Chromosomal,Abnormality, Chromosome,Abnormality, Cytogenetic,Autosome Abnormality,Chromosomal Aberration,Chromosomal Abnormalities,Chromosomal Abnormality,Chromosome Aberration,Chromosome Abnormality,Cytogenetic Aberration,Cytogenetic Abnormality
D005260 Female Females
D006579 Heterozygote An individual having different alleles at one or more loci regarding a specific character. Carriers, Genetic,Genetic Carriers,Carrier, Genetic,Genetic Carrier,Heterozygotes

Related Publications

Kh Kh Semenov, and A M Malashenko
[Fertility of the progeny of female albino mice subjected to local low-frequency vibration].
April 1978, Voprosy okhrany materinstva i detstva,
Kh Kh Semenov, and A M Malashenko
Sterility and semisterility in male progeny of male mice treated with the chemical mutagen TEPA.
June 1971, Toxicology and applied pharmacology,
Kh Kh Semenov, and A M Malashenko
Abnormal zygote development in mice after paternal exposure to a chemical mutagen.
March 1970, Nature,
Kh Kh Semenov, and A M Malashenko
Fertility of male and female mice heterozygous for the reciprocal translocation T(7;17)3BKM.
January 1992, Cytogenetics and cell genetics,
Kh Kh Semenov, and A M Malashenko
[Effect of mutations of chromosome 17 on homolog segregation in the progeny of mice heterozygous for Robertsonian translocation].
January 1984, Doklady Akademii nauk SSSR,
Kh Kh Semenov, and A M Malashenko
[The progeny of male rats subjected to chronic exposure to a permanent magnetic field].
October 1990, Gigiena i sanitariia,
Kh Kh Semenov, and A M Malashenko
Kinetics of oogenesis in mice heterozygous for Robertsonian translocation.
February 1990, Differentiation; research in biological diversity,
Kh Kh Semenov, and A M Malashenko
Changes in Differentiation of Thymic T Cells in the Progeny of Female Mice Subjected to Immune System Stimulation during Early Pregnancy.
March 2016, Bulletin of experimental biology and medicine,
Kh Kh Semenov, and A M Malashenko
Female neuregulin 1 heterozygous mice require repeated exposure to Δ⁹-tetrahydrocannabinol to alter sensorimotor gating function.
November 2013, Pharmacopsychiatry,
Kh Kh Semenov, and A M Malashenko
X chromosome activity in female germ cells of mice heterozygous for Searle's translocation T(X;16)16H.
June 1981, Genetical research,
Copied contents to your clipboard!