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Ampicillin and tetracycline, in doses of 2 g a day, were compared in the treatment of acute exacerbations of chronic bronchitis. Seventy-nine patients were followed for 3 to 29 months and were treated for 118 exacerbations. Clinical improvement occurred after 10 days of treatment with either drug in over 80% of the cases. Haemophilus influenzae and Diplococcus pneumoniae were eradicated from the sputum more than 60% of the time, but in general there was a poor correlation between bacteriological clearing and clinical response. The effect of chemoprophylaxis with ampicillin and tetracycline in doses of 1 g a day on the frequency of acute exacerbations of bronchitis was compared with that of a placebo. Seven hundred eighty prophylactic regimens, consisting of one capsule every 12 hr for 5 days beginning with the first sign of a cold, were prescribed for 76 patients. Irrespective of the regimen, an acute exacerbation of bronchitis was encountered at approximately 13% of the follow-up visits to the clinic.
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
March 1963,
British medical journal,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
September 1965,
Minerva medica,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
January 1966,
British journal of diseases of the chest,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
January 1968,
Marseille medical,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
October 1967,
Minerva medica,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
December 1962,
British medical journal,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
June 1963,
The British journal of clinical practice,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
July 1963,
Deutsche medizinische Wochenschrift (1946),
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
March 1962,
JAMA,
H H Hahn, and
R R MacGregor, and
C K Avent, and
G W Counts, and
H E Smith, and
H N Beaty
September 1965,
Minerva medica,
