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The overall turnover of glutathione in kidney and liver was determined in studies in which L-[(14)C]glutamate was administered to mice. Turnover was much more rapid (about 5 times greater) in kidney than in liver. Studies were also carried out in which 5-oxo-L-[(14)C]proline was administered; the first order rate constants for glutathione synthesis from 5-oxoproline in liver and kidney were not far from those found for synthesis of glutathione from glutamate in these tissues. The findings are in accord with the fact that the activities of the enzymes of the gamma-glutamyl cycle are much higher in kidney than in liver. The findings of high turnover of glutathione in kidney and the rapid utilization of 5-oxoproline by this organ for glutathione synthesis are consistent with the function of the gamma-glutamyl cycle in vivo and the proposed role of gamma-glutamyl derivatives in amino-acid transport.
R Sekura, and
A Meister
January 1976,
Postepy biochemii,
R Sekura, and
A Meister
December 1979,
Proceedings of the National Academy of Sciences of the United States of America,
R Sekura, and
A Meister
December 1983,
Biochemical Society transactions,
R Sekura, and
A Meister
September 1978,
The New England journal of medicine,
R Sekura, and
A Meister
September 1979,
FEBS letters,
R Sekura, and
A Meister
June 1985,
The Journal of biological chemistry,
R Sekura, and
A Meister
November 1970,
Proceedings of the National Academy of Sciences of the United States of America,
R Sekura, and
A Meister
February 1980,
FEBS letters,
R Sekura, and
A Meister
January 1974,
Research publications - Association for Research in Nervous and Mental Disease,
R Sekura, and
A Meister
May 1975,
The Medical clinics of North America,
