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An iodine-labeled beta-adrenergic inhibitor ((125)l-hydroxybenzylpindolol) binds specifically to a site on turkey erythrocyte membranes. A series of beta-adrenergic agonists and inhibitors compete for this binding site, with apparent affinities paralleling biological effectiveness as activators or inhibitors of catecholaminestimulated adenylate cyclase. The activity of d-(+) agonists or inhibitors was 1 percent (or less) than that of the corresponding l-(-) isomers in competing for binding of the iodinated blocker as well as in affecting catecholamine-stimulated adenylate cyclase. 1-(-)-Norepinephrine was about one-tenth as active as l-(-)-isoproterenol in competing for the beta-blocking agent site. The stereospecificity of the interaction with the iodinated beta-blocking agent and the correspondence between affinity for site and biological potency of analogs suggested that this interaction is involved in function of the beta-adrenergic receptor.
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
January 1976,
Drug metabolism and disposition: the biological fate of chemicals,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
July 1988,
Journal of adolescent health care : official publication of the Society for Adolescent Medicine,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
January 1966,
Medizinische Klinik,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
August 1968,
The American journal of cardiology,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
November 1981,
Orvosi hetilap,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
February 1975,
Archives internationales de pharmacodynamie et de therapie,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
September 1975,
Kardiologiia,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
April 1964,
Circulation,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
October 1970,
La Clinica terapeutica,
G D Aurbach, and
S A Fedak, and
C J Woodard, and
J S Palmer, and
D Hauser, and
F Troxler
January 1979,
Journal of clinical pharmacology,
