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In rats hepatocellular cytoplasmic changes after daily repeated D-galactosamine (GalN) intoxication--i.e. subacute GalN intoxication--were studied by light and electron microscopy. The number of GalN injections--and thus the days of survival--was between one and 30. The rats were killed six hours after the last GalN injection. Less degenerative changes were found after repeated GalN injections. An increased formation of atypical dense bodies (ADB), a temporary pronounced lipid accumulation and changes of the rough and smooth endoplasmic reticulum were prominent features of subacute GalN intoxication. The implications with respect to a modified GalN action in subacute GalN intoxication are discussed with special reference to biochemical data obtained in the same experimental model (Schuchhardt et al., 1977).
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
November 1977,
Virchows Archiv. B, Cell pathology,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
January 1977,
Experimentelle Pathologie,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
January 1970,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
March 1983,
Pathology, research and practice,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
January 1977,
Acta morphologica Academiae Scientiarum Hungaricae,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
January 1973,
Journal of medicine,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
February 1970,
The Tohoku journal of experimental medicine,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
July 1970,
Laboratory investigation; a journal of technical methods and pathology,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
January 1966,
Acta biologica et medica Germanica,
H K Koch, and
B Häberle, and
K Meinhardt, and
H Enzan, and
R Lesch
September 1997,
Toxicon : official journal of the International Society on Toxinology,
