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Articular cartilage fragments were added to monolayer cultures of synovial membrane cells. After 3 wk of incubation, the cartilage fragments were examined histologically for metachromasia and basophilia, and for fluorescent staining using a rabbit antiserum to cartilage protein-polysaccharide. Cartilage incubated with cells derived from rheumatoid synovial membranes showed striking loss of metachromasia and basophilia as well as diminished to absent fluorescent staining. Cartilage fragments incubated with cells from normal synovia, or with cells from the synovial membrane of a patient with Reiter's syndrome, did not show these changes and resembled control cartilage incubated in tissue culture medium alone. It appears, therefore, that rheumatoid synovial cells in tissue culture are able to deplete the matrix of articular cartilage.
D Hamerman, and
R Janis, and
C Smith
January 1981,
The Journal of nuclear medicine and allied sciences,
D Hamerman, and
R Janis, and
C Smith
January 1971,
Archivum chirurgicum Neerlandicum,
D Hamerman, and
R Janis, and
C Smith
October 1971,
Acta orthopaedica Belgica,
D Hamerman, and
R Janis, and
C Smith
February 1972,
Biochimica et biophysica acta,
D Hamerman, and
R Janis, and
C Smith
January 1988,
Scandinavian journal of rheumatology. Supplement,
D Hamerman, and
R Janis, and
C Smith
January 1980,
Zeitschrift fur Rheumatologie,
D Hamerman, and
R Janis, and
C Smith
December 1975,
Annals of the rheumatic diseases,
D Hamerman, and
R Janis, and
C Smith
April 1979,
Annals of the rheumatic diseases,
D Hamerman, and
R Janis, and
C Smith
May 1977,
Clinical and experimental immunology,
D Hamerman, and
R Janis, and
C Smith
January 1977,
Arthritis and rheumatism,
