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We describe a radioimmunoassay for rhesus monkey and human immunoreactive calcitonin, in which a selected goat anti-human calcitonin antiserum, 131I-labeled synthetic human calcitonin tracer, and purified synthetic human calcitonin standards were used. The mean basal concentration of calcitonin in normal monkey plasma (254 microgram/liter) was not significantly different from that in normal human plasma (217 microgram/liter). The data indicate that the method is sensitive (lower limit of detection, 5 ng/liter), specific, accurate, and reproducible (coefficient of variation, 1-11% over a wide range of concentrations). Monkey calcitonin response to changes in plasma calcium concentration is similar to that in man, with significant correlation between calcium and calcitonin concentrations. Use of this radioimmunoassay for monkey and human calcitonin allows the monkey to be used in further studies of factors regulating secretion, function, and metabolism of calcitonin under various experimental conditions that would not be feasible in man.
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
April 1976,
Endocrinology,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
July 1981,
World journal of surgery,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
July 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
January 1975,
Fertility and sterility,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
July 1971,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
March 1974,
Clinical chemistry,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
June 1973,
Endocrinology,
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
August 1970,
Lancet (London, England),
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
July 1970,
Lancet (London, England),
G K Hargis, and
W A Reynolds, and
G A Williams, and
W Kawahara, and
B Jackson, and
E N Bowser, and
R M Pitkin
March 1969,
Lancet (London, England),
