Biomaterial Database

The effect of oral potassium supplements on plasma potassium in normokalaemic and hypokalaemic patients. 1977

M A Arif, and S Eaton

Thirteen out of 44 patients taking bendrofluazide 10 mg daily became hypokalaemic over a period of three months. Oral potassium supplements of 3.6 grams daily (48 mmol) given in addition to bendrofluazide for a further period of 3 months raised plasma potassium level significantly in hypokalaemic patients only. We conclude that where patients on diuretic therapy are followed up with plasma potassium measurements, it is generally necessary to prescribe oral potassium in the presence of hypokalaemia only.

UI	MeSH Term	Description	Entries
D007008	Hypokalemia	Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)	Hypopotassemia,Hypokalemias,Hypopotassemias
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011188	Potassium	An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D001539	Bendroflumethiazide	A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810)	Bendrofluazide,Aprinox,Benzide,Benzide-M,Berkozide,Centyl,Esberizid,Naturetin,Naturine,Neo-NaClex,Pluryl,Urizid,Benzide M,Neo NaClex