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The importance of interferon for the prophylaxis of rabies is not yet fully understood. About 50% of cynomolgus monkeys infected with rabies virus could be protected from the disease with human interferon which was administered at a total dose of 1--10 million units per animal either intramuscularly 24 hours after infection or by intralumbar injection up to 11 days after. The clinical relevance of the findings is discussed.
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