-transparent.png){kind=logo}
The first case of gamma-heavy chain disease described in Spain is here reported. The patient, a 36-year-old woman, presented fever, enlarged regional lymph nodes, and hepatosplenomegaly, without bone marrow abnormalities but with lymphopenia. Serum electrophoresis did not disclose any M-component. The abnormal gamma-chain protein had a alpha2-globulin mobility and was immunochemically related to the Fc fragment. It belonged to the IgG 4 subclass, its molecular weight was about 60,000. Proteinuria was minimal but the electrophoresis of concentrated urine showed a homogeneous peak of alpha2-globulin mobility constituted by the gamma-chain fragment. Biopsy of an axillary lymph node disclosed features of immunoblastic sarcoma. The course was malignant, resulting in death in 8 months.
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
March 1975,
La Nouvelle presse medicale,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
December 1978,
Problemy gematologii i perelivaniia krovi,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
December 1978,
Problemy gematologii i perelivaniia krovi,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
January 1975,
Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
February 1982,
Scandinavian journal of haematology,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
January 1979,
Vox sanguinis,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
January 1979,
Vox sanguinis,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
January 2020,
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
January 1971,
Nouvelle revue francaise d'hematologie,
M T Gallart, and
J Canals, and
E Cañadell, and
L Cortez, and
A Moragas, and
S Schwartz
April 1979,
Minerva medica,
