Biomaterial Database

[Effect of flunarizine (sibelium) on the arterial blood flow (author's transl)]. 1978

J De Cree, and H Geukens, and H Verhaegen

31 patients with intermittent claudication were treated with 10 mg Flunarizine (Sibelium) daily for 6 months. Before the beginning of the trial and after a period of 6 months, a plethysmographic examination was undertaken to determine the reactive hyperemia elicited by a temporary arterial occlusion. 25 patients showed an improvement in at least one of the parameters measured during the reactive hyperemia. Lengthening of the walking distance was also seen at the same time in 24 of these patients. In a further analysis of our results it was shown that in each of the 25 patients those parameters of the reactive hyperemia improved which had deviated furthest from the normal.

UI	MeSH Term	Description	Entries
D007383	Intermittent Claudication	A symptom complex characterized by pain and weakness in SKELETAL MUSCLE group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial STENOSIS; muscle ISCHEMIA; and accumulation of LACTATE.	Claudication, Intermittent
D008134	Long-Term Care	Care over an extended period, usually for a chronic condition or disability, requiring periodic, intermittent, or continuous care.	Care, Long-Term,Long Term Care
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D010991	Plethysmography	Recording of change in the size of a part as modified by the circulation in it.	Plethysmographies
D004359	Drug Therapy, Combination	Therapy with two or more separate preparations given for a combined effect.	Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006940	Hyperemia	The presence of an increased amount of blood in a body part or an organ leading to congestion or engorgement of blood vessels. Hyperemia can be due to increase of blood flow into the area (active or arterial), or due to obstruction of outflow of blood from the area (passive or venous).	Active Hyperemia,Arterial Hyperemia,Passive Hyperemia,Reactive Hyperemia,Venous Congestion,Venous Engorgement,Congestion, Venous,Engorgement, Venous,Hyperemia, Active,Hyperemia, Arterial,Hyperemia, Passive,Hyperemia, Reactive,Hyperemias,Hyperemias, Reactive,Reactive Hyperemias