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The effects of growth hormone (GH) in vitro on phenylalanine-14C incorporation to assess protein synthesis and on alpha-aminoisobutyric-1-3H accumulation to measure amino acid transport in the diaphragm muscle of the rat were investigated 2, 6 and 24 h after hypophysectomy or sham-operation. In hypophysectomized animals protein synthesis was depressed. GH in vitro was without effect 2 h after hypophysectomy but stimulated protein synthesis 6 and 24 h after the operation. Six hours after hypophysectomy amino acid transport was enhanced and further stimulated by GH. After 24 h amino acid transport was depressed but was stimulated to normal levels by GH. Six hours after sham-operation protein synthesis was depressed, but was stimulated by GH. After 24 h protein synthesis was normalized and GH was without effect. GH did not influence amino acid transport after sham-operation. Plasma levels of GH were undetectable after hypophysectomy, markedly depressed 2 and 6 h after sham-operation, but normal after 24 h. It is concluded that tissue responsiveness to GH develops a few hours after hypophysectomy.
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
January 1968,
Acta endocrinologica,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
April 1967,
Acta endocrinologica,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
April 1985,
Acta physiologica Scandinavica,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
February 1968,
Annals of the New York Academy of Sciences,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
January 1969,
Acta physiologica Scandinavica,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
July 1964,
Endocrinology,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
April 1965,
Life sciences (1962),
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
November 1962,
The American journal of physiology,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
May 1978,
Endocrinology,
K Albertsson-Wirkland, and
S Edén, and
O Isaksson
December 1959,
Science (New York, N.Y.),
