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Weanling male Holtzman rats were fed calcium.deficient, phosphorus-deficient, or control diets for 8 wk. Parathyroid hormone (PTH) was measured by radioimmunoassay, and 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) by a competitive binding assay. Rats fed the calcium-deficient diet (0.01% calcium, 0.6% phosphorus) became mildly hypocalcemic after 6 days. Serum calcium levels reached 5.5 +/- 0.4 mg/dl (mean +/- SD) in 5 wk (control 10.3 +/- 0.4 mg/dl). PTH increased from 285 +/- 112 to 3658 +/- 428 pg/ml within 6 wk. Maximum serum levels of 1,25(OH)2D3 (111.8 +/- 17.3 vs. control 11.4 +/- 3.8 ng/dl) were reached at 3 wk and thereafter declined to 44.6 +/- 14.0 ng/dl. In rats fed the phosphorus-deficient diet (0.6% calcium, 0.04% phosphorus), serum phosphorus fell within 24 h from 9.1 +/- 0.6 to 3.2 +/- 0.1 mg/dl, recovered to 5.6 +/- 0.4 mg/dl for 2-3 days, and then declined again. Serum calcium reached a maximum of 14.4 +/- 0.4 mg/dl at day 2 (control 10.8 +/- 0.5 mg/dl) and then slowly declined. PTH decreased within 24 h from 243 +/- 59 to 36 +/- 0 pg/ml in phosphorus-depleted rats. Serum levels of 1,25(OH)2D3 increased within 24 h and remained elevated after 6 wk of phosphorus deprivation (61.2 +/- 11.7 ng/dl vs. control 18.3 +/- 0.4 ng/dl).
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
June 1982,
Endocrinology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
March 1988,
The Biochemical journal,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
July 1981,
The American journal of pathology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
May 1978,
Archives of biochemistry and biophysics,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
October 2017,
The Journal of steroid biochemistry and molecular biology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
February 1980,
The American journal of physiology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
August 1975,
The American journal of physiology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
March 1984,
The American journal of physiology,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
January 1981,
Calcified tissue international,
J I Rader, and
D J Baylink, and
M R Hughes, and
E F Safilian, and
M R Haussler
April 2010,
Domestic animal endocrinology,
