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To investigate the role of ventilation-perfusion (VA/Q) imbalance in the hypoxemia observed after head injury, 5 male subjects (17 to 26 years of age) with isolated head trauma and subsequent hypoxemia were studied. Disturbances of ventilation and perfusion were assessed using the steady-state elimination of six inert gases of different solubilities. Paired studies were conducted during mechanical ventilation with a volume-cycled ventilator and during spontaneous ventilation. Distributions recovered from studies of spontaneous ventilation show a mode of ventilation and perfusion near a VA/Q of 1.0. In addition, 41% of the cardiac output was distributed to a second population of lung units with low VA/Q (less than 0.1) and shunt. During mechanical ventilation, perfusion to these regions of low VA/Q decreased to 21% of the cardiac output, whereas shunt fraction was unchanged. This was associated with a marked broadening of the VA/Q mode near 1.0, relative to the studies during spontaneous ventilation. Mean functional residual capacity during mechanical ventilation was not different from that during spontaneous ventilation. These results suggest that head injury can lead to hypoxemia through a failure of VA/Q regulatory mechanisms.
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
June 1983,
The International journal of pediatric nephrology,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
February 1976,
Circulation,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
June 2009,
Journal of applied physiology (Bethesda, Md. : 1985),
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
January 2010,
Prehospital emergency care,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
August 1990,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
February 1984,
Journal of applied physiology: respiratory, environmental and exercise physiology,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
February 1963,
Clinical science,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
October 1984,
Middle East journal of anaesthesiology,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
September 2022,
Sleep & breathing = Schlaf & Atmung,
P T Schumacker, and
G R Rhodes, and
J C Newell, and
R E Dutton, and
D M Shah, and
W A Scovill, and
S R Powers
January 1998,
Neurologia i neurochirurgia polska,
