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In a study of electrolytes in lumbar cerebrospinal fluid (csf) from psychiatric patients, the authors found a positive correlation between calcium concentration and symptom severity in hospitalized depressed patients. CSF calcium levels tended to decrease as patients improved. In four rapidly cycling patients, CSF calcium was higher during depression than during mania. Mean CSF calcium for the depressed patients as a group was not significantly different from neurological controls or other psychiatric patients. Symptom remission from acute psychosis in schizophrenic patients was accompanied by a significant increase in CSF calcium concentration. These findings are discussed in relationship to calcium-induced alterations in neuronal and physiological excitability.
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
January 1985,
Psychiatric medicine,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
April 1983,
Archives of general psychiatry,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
February 1978,
The American journal of psychiatry,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
November 1982,
The British journal of psychiatry : the journal of mental science,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
January 1985,
Progress in neuro-psychopharmacology & biological psychiatry,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
April 1991,
Biological psychiatry,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
January 2007,
Comprehensive psychiatry,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
September 1988,
Acta psychiatrica Scandinavica,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
January 1978,
Psychiatria clinica,
D C Jimerson, and
R M Post, and
J S Carman, and
D P van Kammen, and
J H Wood, and
F K Goodwin, and
W E Bunney
January 1990,
Pharmacology & toxicology,
