BIOMAT Database Logo BIOMAT Database Logo

A rapid bioassay system for lead using young Japanese quail. 1979

C L Stone, and K R Mahaffey, and M R Fox

A rapid bioassay of lead was established in young japanese quail. Each group of 10 day-old birds received deionized water and a purified diet ad libitum for 2 wk. The diet contained 0.2 microgram lead/g. Lead acetate was added to give 14.8, 34.4, 51.2, 74.4, 234, 563, or 1223 microgram total lead/g by analysis. The duodenum, kidneys, liver and tibias were assayed for lead. Consumption of a diet containing either 563 or 1223 ppm lead caused a decrease (P less than or equal to 0.05) in body weight after 1 wk and an increase in free erythrocyte protoporphyrin after 2wk. Inhibition of red blood cell delta-aminolevulinic acid dehydratase (RBC-ALAD) activity occurred in birds consuming as little as 14.8 ppm lead. Packed cell volumes and hemoglobin concentrations were not affected by the dietary treatments. Lead concentrations in tissues from birds fed the lowest level of added lead were greater than those found in the corresponding tissues of control birds. The concentration of lead in the tibia showed the most distinguishable group means and the most nearly linear response; the highest slope was between 14.8 and 110 ppm dietary lead, using log-log transformations. The rapid bioassay is suitable for investigating high lead foods.

UI MeSH Term Description Entries
D007854 Lead A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297 Male Males
D009929 Organ Size The measurement of an organ in volume, mass, or heaviness. Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D011784 Quail Common name for two distinct groups of BIRDS in the order GALLIFORMES: the New World or American quails of the family Odontophoridae and the Old World quails in the genus COTURNIX, family Phasianidae. Quails
D003370 Coturnix A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL. Japanese Quail,Coturnix japonica,Japanese Quails,Quail, Japanese,Quails, Japanese
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260 Female Females
D005506 Food Contamination The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage. Food Adulteration,Adulteration, Food,Adulterations, Food,Contamination, Food,Contaminations, Food,Food Adulterations,Food Contaminations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions

Related Publications

C L Stone, and K R Mahaffey, and M R Fox
Bioavailability of lead in oysters fed to young Japanese Quail.
December 1981, Environmental research,
C L Stone, and K R Mahaffey, and M R Fox
Testicular response in Japanese quail as a bioassay of pituitary gonadotropins.
July 1966, American journal of veterinary research,
C L Stone, and K R Mahaffey, and M R Fox
Toxicity of dietary lead in Japanese quail.
September 1975, Poultry science,
C L Stone, and K R Mahaffey, and M R Fox
Experimental aflatoxicosis in young Japanese quail.
May 1982, Poultry science,
C L Stone, and K R Mahaffey, and M R Fox
The need for dietary choline by young Japanese quail.
November 1973, Poultry science,
C L Stone, and K R Mahaffey, and M R Fox
Rapid photoperiodic responses in Japanese quail: is daylength measurement based upon a circadian system?
January 1987, Journal of biological rhythms,
C L Stone, and K R Mahaffey, and M R Fox
Evaluation of Japanese quail as a model system for avian transgenesis using avian leukosis viruses.
February 1999, Poultry science,
C L Stone, and K R Mahaffey, and M R Fox
Whole brain acetylcholinesterase activity in lead-exposed Japanese quail.
July 1985, Poultry science,
C L Stone, and K R Mahaffey, and M R Fox
Tissue lead concentrations in Japanese quail ingesting lead pellets or shot with lead pellets.
May 1981, Bulletin of environmental contamination and toxicology,
C L Stone, and K R Mahaffey, and M R Fox
A simulated eye for vitreous surgery using Japanese quail eggs.
June 2013, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
Copied contents to your clipboard!