Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi. 1979

L P Amsel, and L Cravitz, and R VanderWyk, and S Zahry

Undecylenic acid and tolnaftate were tested in an in vitro test system to evaluate their relative "killing time" efficacy against Trichophyton mentagrophytes, Trichophyton rubrum, and Epidermophyton floccosum. Commercial products containing these active agents were tested similarly. The pure active agents were equivalent in activity. The commercial product containing undecylenic acid appeared to be more effective against the test organisms than did the product containing tolnaftate.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D004821 Epidermophyton A fungal genus which grows in the epidermis and is the cause of TINEA. Epidermophytons
D014008 Tinea Pedis Dermatological pruritic lesion in the feet, caused by Trichophyton rubrum, T. mentagrophytes, or Epidermophyton floccosum. Athlete's Foot,Athlete Foot,Athletes Foot
D014047 Tolnaftate A synthetic antifungal agent. Aftate,Breezee,Chinofungin,Chlorisept,Curatin,Genaspor,Micoisdin,NP-27,Ony-Clear,Sporiline,Tinactin,Tinaderm,Tinatox,Tineafax,Ting,Tolnaftat Purder N,Tonoftal,ZeaSorb,NP 27,NP27,Ony Clear,Purder N, Tolnaftat
D014249 Trichophyton A mitosporic fungal genus and an anamorphic form of Arthroderma. Various species attack the skin, nails, and hair. Endodermophyton,Trychophyton,Endodermophytons,Trichophytons,Trychophytons
D014476 Undecylenic Acids Salts and derivatives of undecylenic acid. Undecylenates,Undecylenic Acid Dervatives

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