BIOMAT Database Logo BIOMAT Database Logo

Ergot alkaloids. Synthesis of nitrosourea derivatives of ergolines as potential anticancer agents. 1979

A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens

Nitrosourea derivatives of ergolines have been synthesized for the purpose of obtaining agents with both prolactin-and tumor-inhibitory activity. Two derivatives of 8-amino-6-methylergoline (3), 8-[3-(2-chloroethyl)-3-nitrosoureido]-1-nitroso-6-methylergoline (5c) and 8-[3-2-chloroethyl)-3-nitrosoureido]-6-methylergoline (5a), have been prepared. In addition, nitroso (7) and chloroethylcarbamyl (8) derivatives of elymoclavine (6) are reported. Compounds 5a and 5c have activity against L1210 leukemia in mice but only moderate prolactin-inhibiting activity. The chloroethylcarbamyl derivative 8 of elymoclavine is a potent prolacting inhibitor.

UI MeSH Term Description Entries
D007939 Leukemia L1210 An experimental LYMPHOCYTIC LEUKEMIA of mice. Leukemia L 1210,L 1210, Leukemia,L1210, Leukemia
D009607 Nitrosourea Compounds A class of compounds in which the core molecule is R-NO, where R is UREA. Compounds, Nitrosourea
D011388 Prolactin A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate. Lactogenic Hormone, Pituitary,Mammotropic Hormone, Pituitary,Mammotropin,PRL (Prolactin),Hormone, Pituitary Lactogenic,Hormone, Pituitary Mammotropic,Pituitary Lactogenic Hormone,Pituitary Mammotropic Hormone
D004873 Ergolines A series of structurally-related alkaloids that contain the ergoline backbone structure. Ergoline
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000970 Antineoplastic Agents Substances that inhibit or prevent the proliferation of NEOPLASMS. Anticancer Agent,Antineoplastic,Antineoplastic Agent,Antineoplastic Drug,Antitumor Agent,Antitumor Drug,Cancer Chemotherapy Agent,Cancer Chemotherapy Drug,Anticancer Agents,Antineoplastic Drugs,Antineoplastics,Antitumor Agents,Antitumor Drugs,Cancer Chemotherapy Agents,Cancer Chemotherapy Drugs,Chemotherapeutic Anticancer Agents,Chemotherapeutic Anticancer Drug,Agent, Anticancer,Agent, Antineoplastic,Agent, Antitumor,Agent, Cancer Chemotherapy,Agents, Anticancer,Agents, Antineoplastic,Agents, Antitumor,Agents, Cancer Chemotherapy,Agents, Chemotherapeutic Anticancer,Chemotherapy Agent, Cancer,Chemotherapy Agents, Cancer,Chemotherapy Drug, Cancer,Chemotherapy Drugs, Cancer,Drug, Antineoplastic,Drug, Antitumor,Drug, Cancer Chemotherapy,Drug, Chemotherapeutic Anticancer,Drugs, Antineoplastic,Drugs, Antitumor,Drugs, Cancer Chemotherapy
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis of nitrosourea derivatives of pyridine and piperidine as potential anticancer agents.
August 1980, Journal of medicinal chemistry,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Ergot alkaloids. New ergolines as selective dopaminergic stimulants.
August 1978, Journal of medicinal chemistry,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis of nitrosourea derivatives of sucrose as central nervous system anticancer agents.
October 1977, Journal of medicinal chemistry,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Ergot alkaloids. Ergolines and related compounds as inhibitors of prolactin release.
March 1974, Journal of medicinal chemistry,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents.
April 2019, Molecules (Basel, Switzerland),
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis and Evaluation of Bakuchiol Derivatives as Potential Anticancer Agents.
February 2018, Molecules (Basel, Switzerland),
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis and characterisation of celastrol derivatives as potential anticancer agents.
December 2017, Journal of enzyme inhibition and medicinal chemistry,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Synthesis of oxamide-hydrazone hybrid derivatives as potential anticancer agents.
February 2023, Research in pharmaceutical sciences,
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Design, synthesis of novel quinazolone alkaloids derivatives as potential antitumor agents.
July 2011, Medicinal chemistry (Shariqah (United Arab Emirates)),
A M Crider, and C K Lu, and H G Floss, and J M Cassady, and J A Clemens
Benzimidazole derivatives as potential anticancer agents.
March 2013, Mini reviews in medicinal chemistry,
Copied contents to your clipboard!