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Albino rats of 1, 5, 9, 16, and 25 days of age were sacrificed, and six brain regions were dissected free. Crude synaptosomal preparations from each brain region and age were obtained by differential centrifugation. Protein content in these fractions from the six brain regions increased almost threefold between 1 and 25 days of age. The preparations were delipidated, solubilized, and subjected to polyacrylamide gel electrophoresis. The densitometric patterns of five samples from each age and brain region were analyzed for changes in the relative amount of stained protein bands. Of the polyacrylamide gel-separated protein bands, 16 regional differences at specific ages and 20 developmental changes in specific brain regions were found to be statistically significant. The hippocampal region showed the greatest number of statistical changes in the protein pattern as a function of age, whereas the cerebellum showed none. The results suggest the importance of considering regional differences in studies of biochemical developmental changes.
L G Davis, and
E G Brunngraber, and
A Routtenberg
December 2001,
Brain research. Molecular brain research,
L G Davis, and
E G Brunngraber, and
A Routtenberg
January 1980,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
L G Davis, and
E G Brunngraber, and
A Routtenberg
December 1979,
Neurochemical research,
L G Davis, and
E G Brunngraber, and
A Routtenberg
March 1966,
Journal of clinical pathology,
L G Davis, and
E G Brunngraber, and
A Routtenberg
January 1987,
Caries research,
L G Davis, and
E G Brunngraber, and
A Routtenberg
October 1981,
Brain research,
L G Davis, and
E G Brunngraber, and
A Routtenberg
January 1973,
Journal of neurobiology,
L G Davis, and
E G Brunngraber, and
A Routtenberg
August 1977,
Medical biology,
L G Davis, and
E G Brunngraber, and
A Routtenberg
January 1953,
Revue d'immunologie et de therapie antimicrobienne,
L G Davis, and
E G Brunngraber, and
A Routtenberg
October 1948,
Archives of biochemistry,
