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The influence of Methylprednisolone (1.2 mg/kg body weight daily for 14 days) on the physiological cell renewal of gastric and intestinal mucosa was examined autoradiographically by determination of the 3H-labelling index and the cell cycle of the regenerating epithelial cells. Macroscopical or microscopical changes of the gastric or intestinal mucosa could not be observed. The labelling index was not significantly altered compared to the controls. Against this the determination of the cell cycle showed a clear inhibition of epithelial cell proliferation in all parts of the gastrointestinal tract with a prolongation of the postmitotic phase, a small inhibition of the DNA synthesis and a corresponding prolongation of the mean generation time.
H J Castrup, and
A Reiss, and
K Neumann
April 1974,
Deutsche medizinische Wochenschrift (1946),
H J Castrup, and
A Reiss, and
K Neumann
February 1977,
Pathologie-biologie,
H J Castrup, and
A Reiss, and
K Neumann
August 1974,
Fukuoka igaku zasshi = Hukuoka acta medica,
H J Castrup, and
A Reiss, and
K Neumann
January 1972,
Digestion,
H J Castrup, and
A Reiss, and
K Neumann
May 1981,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
H J Castrup, and
A Reiss, and
K Neumann
November 1974,
The Medical clinics of North America,
H J Castrup, and
A Reiss, and
K Neumann
January 2016,
Uspekhi fiziologicheskikh nauk,
H J Castrup, and
A Reiss, and
K Neumann
November 1980,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
H J Castrup, and
A Reiss, and
K Neumann
January 1981,
Deutsche Zeitschrift fur Verdauungs- und Stoffwechselkrankheiten,
H J Castrup, and
A Reiss, and
K Neumann
January 1980,
Horumon to rinsho. Clinical endocrinology,
