BIOMAT Database Logo BIOMAT Database Logo

Effects of tolbutamide on insulin and glucagon secretion of the isolated perfused rat pancreas. 1971

H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer

UI MeSH Term Description Entries
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007515 Islets of Langerhans Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN. Islands of Langerhans,Islet Cells,Nesidioblasts,Pancreas, Endocrine,Pancreatic Islets,Cell, Islet,Cells, Islet,Endocrine Pancreas,Islet Cell,Islet, Pancreatic,Islets, Pancreatic,Langerhans Islands,Langerhans Islets,Nesidioblast,Pancreatic Islet
D008297 Male Males
D010179 Pancreas A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.
D010477 Perfusion Treatment process involving the injection of fluid into an organ or tissue. Perfusions
D003864 Depression, Chemical The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical. Chemical Depression,Chemical Depressions,Depressions, Chemical
D004357 Drug Synergism The action of a drug in promoting or enhancing the effectiveness of another drug. Drug Potentiation,Drug Augmentation,Augmentation, Drug,Augmentations, Drug,Drug Augmentations,Drug Potentiations,Drug Synergisms,Potentiation, Drug,Potentiations, Drug,Synergism, Drug,Synergisms, Drug
D005934 Glucagon A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511) Glucagon (1-29),Glukagon,HG-Factor,Hyperglycemic-Glycogenolytic Factor,Proglucagon (33-61),HG Factor,Hyperglycemic Glycogenolytic Factor
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000078790 Insulin Secretion Production and release of insulin from PANCREATIC BETA CELLS that primarily occurs in response to elevated BLOOD GLUCOSE levels. Secretion, Insulin

Related Publications

H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
[Action of tolbutamide on glucagon secretion. II. Study on the isolated and perfused rat pancreas].
January 1972, Comptes rendus des seances de la Societe de biologie et de ses filiales,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
[Insulin and glucagon secretion in the isolated perfused rat pancreas].
January 1976, Acta biologica et medica Germanica,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Effects of salicylate on insulin and glucagon secretion by the isolated and perfused rat pancreas.
December 1984, Revista espanola de fisiologia,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Different effects of hypothermia on insulin and glucagon secretion from the isolated perfused rat pancreas.
April 1980, Diabetologia,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Effects of caerulein and bombesin on insulin and glucagon secretion from the isolated, perfused rat pancreas.
March 1982, Regulatory peptides,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Effect of corticosterone on insulin and glucagon secretion by the isolated perfused rat pancreas.
February 1980, Endocrinology,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Effects of imidazoline derivative RX871024 on insulin, glucagon, and somatostatin secretion from isolated perfused rat pancreas.
November 1998, Biochemical and biophysical research communications,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
Adrenergic modulation of insulin and glucagon secretion from the isolated perfused rat pancreas.
June 1981, Endocrinologia japonica,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
[Effects of sodium DL lactate on secretion of insulin and glucagon. Study on the isolated perfused rat pancreas].
January 1974, Comptes rendus des seances de la Societe de biologie et de ses filiales,
H Laube, and R Fussgänger, and R Goberna, and K Schröder, and K Straub, and K Sussman, and E F Pfeiffer
[Interaction between tolbutamide and theophylline, as studied on insulin secretion by the isolated, perfused rat pancreas].
January 1973, Comptes rendus des seances de la Societe de biologie et de ses filiales,
Copied contents to your clipboard!