Biomaterial Database

Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma. 1973

J B Peter, and W Fiehn

Myotonia induced in rats by 20,25-diazacholesterol is accompanied by accumulation of desmosterol in serum, fragmented sarcoplasmic reticulum, and sarcolemma. Activities of (Na(+),K(+))- and Ca(2+)-stimulated adenosine triphosphatases of the sarcolemma are increased, but not the Mg(2+)-stimulated adenosine triphosphatase. The altered sterol composition of the sarcolemma may cause this type of myotonia by decreasing the chloride conductance of the membrane.

UI	MeSH Term	Description	Entries
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009222	Myotonia	Prolonged failure of muscle relaxation after contraction. This may occur after voluntary contractions, muscle percussion, or electrical stimulation of the muscle. Myotonia is a characteristic feature of MYOTONIC DISORDERS.	Myotonic Phenomenon,Percussion Myotonia,Myotonia, Percussion,Myotonias,Myotonias, Percussion,Myotonic Phenomenons,Percussion Myotonias,Phenomenon, Myotonic,Phenomenons, Myotonic
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D003897	Desmosterol	An intermediate in the synthesis of cholesterol.	24-Dehydrocholesterol,Demosterol,24 Dehydrocholesterol
D005260	Female		Females
D000251	Adenosine Triphosphatases	A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.	ATPases,Adenosinetriphosphatase,ATPase,ATPase, DNA-Dependent,Adenosine Triphosphatase,DNA-Dependent ATPase,DNA-Dependent Adenosinetriphosphatases,ATPase, DNA Dependent,Adenosinetriphosphatases, DNA-Dependent,DNA Dependent ATPase,DNA Dependent Adenosinetriphosphatases,Triphosphatase, Adenosine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001372	Aza Compounds	Organic chemicals where carbon atoms have been replaced by nitrogen atoms.	Compounds, Aza
D012508	Sarcolemma	The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)	Sarcolemmas
D012519	Sarcoplasmic Reticulum	A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.	Reticulum, Sarcoplasmic,Reticulums, Sarcoplasmic,Sarcoplasmic Reticulums