Biomaterial Database

[Changes in the thyroid gland in Itsenko-Cushing's disease and corticosteroma]. 1979

V B Banina, and N P Dmitrieva

Histological and ultrastructural examinations and stereological analysis of the thyroid gland of 16 patients with Itsenko--Cushing disease and corticosteroma with glucocorticoid hyperproduction showed signs of a decrease in its functional activity. An increase in the colloid mass in follicles was accompanied by its irregular staining, flattening of the epithelium, lipomatosis of the stroma and ultrastructural signs of low activity of thyreocytes. The assumption of a spherical shape of the follicles was shown to be unjustified. The accurate quantitative evaluation of the structural changes in the thyroid gland requires information on the spacial organization of its components and shape of individual follicles.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D003480	Cushing Syndrome	A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.	Cushing's Syndrome,Hypercortisolism,Syndrome, Cushing,Syndrome, Cushing's
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000314	Adrenal Rest Tumor	Neoplasm derived from displaced cells (rest cells) of the primordial ADRENAL GLANDS, generally in patients with CONGENITAL ADRENAL HYPERPLASIA. Adrenal rest tumors have been identified in TESTES; LIVER; and other tissues. They are dependent on ADRENOCORTICOTROPIN for growth and adrenal steroid secretion.	Adrenal Cortical Rest Tumor,Adrenal Rest Tumors,Rest Tumor, Adrenal,Rest Tumors, Adrenal,Tumor, Adrenal Rest,Tumors, Adrenal Rest
D001344	Autopsy	Postmortem examination of the body.	Autopsies,Post-Mortem Examination,Postmortem Examination,Examination, Post-Mortem,Examination, Postmortem,Examinations, Post-Mortem,Examinations, Postmortem,Post Mortem Examination,Post-Mortem Examinations,Postmortem Examinations
D013961	Thyroid Gland	A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.	Thyroid,Gland, Thyroid,Glands, Thyroid,Thyroid Glands,Thyroids