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Twenty-one patients in severe congestive heart failure refractory to conventional medical management were treated with sodium nitroprusside on 22 occasions. On 14 occasions (responders) there was significant improvement in clinical and haemodynamic indices. On 8 occasions (non-responders) hypotension developed without haemodynamic improvement and nitroprusside treatment had to be abandoned. The initial mean arterial pressure and the capillary wedge pressure tended to be higher in the responders while the cardiac index tended to be higher in the non-responders. The systemic vascular resistance was higher in the responders than in the non-responders (2560 +/- 160 vs 1800 +/- 180 dynes s cm-5, P less than 0.001). All of the responders had systemic vascular resistance greater than 1900 dynes s cm-5, while only one of the non-responders had a systemic vascular resistance in this range. Thus, a variable response to vasodilator therapy for congestive cardiac failure is documented. The favourable response appears to be limited to patients with a high systemic vascular resistance.
S A Lukes, and
C A Romero, and
L Resnekov
September 2007,
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S A Lukes, and
C A Romero, and
L Resnekov
January 1987,
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S A Lukes, and
C A Romero, and
L Resnekov
January 1979,
Zhonghua xin xue guan bing za zhi,
S A Lukes, and
C A Romero, and
L Resnekov
July 1983,
Kardiologiia,
S A Lukes, and
C A Romero, and
L Resnekov
November 1977,
The New England journal of medicine,
S A Lukes, and
C A Romero, and
L Resnekov
January 1985,
European journal of clinical pharmacology,
S A Lukes, and
C A Romero, and
L Resnekov
May 1988,
European heart journal,
S A Lukes, and
C A Romero, and
L Resnekov
February 1980,
Circulation,
S A Lukes, and
C A Romero, and
L Resnekov
January 1986,
Journal of cardiovascular pharmacology,
S A Lukes, and
C A Romero, and
L Resnekov
April 1997,
Lancet (London, England),
