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A means of determination of a ctive hydrogen of hydroxyl, carboxyl, sulfhydryl, amino, amido and sulfonamido groups by chemical ionization mass spectrometry using ammonia and trideuterioammonia as reagent gases is described. The method is based on exchange of active hydrogen for deuterium occurring during the chemical ionization process using trideuterioammonia, with comparison of m/z for ammonium adduct [M + NH1]+ and trideuterioammonium adduct [M--nH + nD + ND4]+, or of protonated molecular ion [M + H]+ and deuteronated molecular ion [M--nH + nD + D]+ yielding the number of active hydrogens. Applications have been made to several classes of biologically important compounds.
Y Y Lin, and
L L Smith
January 1973,
Advances in biochemical psychopharmacology,
Y Y Lin, and
L L Smith
September 1980,
Lipids,
Y Y Lin, and
L L Smith
October 1970,
Analytical chemistry,
Y Y Lin, and
L L Smith
January 1975,
Biochemical Society transactions,
Y Y Lin, and
L L Smith
January 1976,
IARC scientific publications,
Y Y Lin, and
L L Smith
October 1972,
The Journal of physical chemistry,
Y Y Lin, and
L L Smith
July 1971,
Biochimica et biophysica acta,
Y Y Lin, and
L L Smith
January 1979,
Gastroenterologia Japonica,
Y Y Lin, and
L L Smith
January 1978,
Journal of forensic sciences,
