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Carbohydrate metabolism by four rat hepatoma cell lines in culture, namely, Reuber H35, MH1C1, RLC, and HTC, has been investigated. Glucose utilization by H35 and MH1C1 cells is lower than that by RLC and HTC cells. The four cell lines also differ with respect to the accumulation of lactic acid in the growth medium; in particular, H35 cells show uptake of lactic acid, rather than accumulation in the medium. Specific activities of a number of enzymes involved in glycolysis, gluconeogenesis, pentose phosphate pathway, and glycogen formation were determined in the four cell lines. A direct relationship between the differences was found for the activities of some enzymes belonging to carbohydrate metabolism, namely, hexokinase, pyruvate kinase, aldolases A and B, glucose-6-phosphate dehydrogenase, and phosphogluconate dehydrogenase and the differences found for glucose utilization by the different cell lines.
D H Schamhart, and
K W van de Poll, and
R van Wijk
January 1974,
The Journal of cell biology,
D H Schamhart, and
K W van de Poll, and
R van Wijk
October 2000,
Journal of biochemistry,
D H Schamhart, and
K W van de Poll, and
R van Wijk
January 1976,
Journal of cyclic nucleotide research,
D H Schamhart, and
K W van de Poll, and
R van Wijk
May 1981,
Cell biology international reports,
D H Schamhart, and
K W van de Poll, and
R van Wijk
July 1979,
Cancer research,
D H Schamhart, and
K W van de Poll, and
R van Wijk
May 1981,
Molecular pharmacology,
D H Schamhart, and
K W van de Poll, and
R van Wijk
January 1993,
Cell biology and toxicology,
D H Schamhart, and
K W van de Poll, and
R van Wijk
January 1981,
Endocrinology,
D H Schamhart, and
K W van de Poll, and
R van Wijk
March 1987,
Cancer research,
D H Schamhart, and
K W van de Poll, and
R van Wijk
January 1988,
The International journal of biochemistry,
