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Measurement by radioimmunoassay of plasma norethisterone (NE) has been used to compare the bioavailability of tablets containing ethynodiol diacetate (EDA) with that of a standard oral solution of this progestogen in 12 normal women. The tablets investigated were from three batches which showed different in vitro dissolution rates. There were no significant differences in the bioavailability of the tablet formulations, which were essentially bioequivalent to the solution. Peak blood levels of NE were reached within 4h of EDA administration in solution or tablets. After the peak, NE plasma levels declined in two phases, with a mean terminal elimination half lives of 4 to 6.9h. The pharmacokinetics of NE after EDA administration showed some similarity to those observed by other workers after oral doses of NE itself.
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
February 1977,
Journal of steroid biochemistry,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
May 1972,
Xenobiotica; the fate of foreign compounds in biological systems,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
June 1985,
Contraception,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
January 1983,
Hormone research,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
December 1966,
British medical journal,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
January 1982,
Hormone research,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
February 1968,
The Medical journal of Australia,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
March 1968,
The Medical journal of Australia,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
March 1976,
European journal of clinical pharmacology,
C W Vose, and
J K Butler, and
B M Williams, and
J E Stafford, and
J R Shelton, and
D A Rose, and
R F Palmer, and
A M Breckenridge, and
M L Orme, and
M J Serlin
April 1966,
Lyon medical,
