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Gynaecomastia has occurred unilaterally or bilaterally in five out of 25 male duodenal ulcer patients after more than four months treatment with cimetidine 1.6 g daily. All elected to continue treatment to 12 months and their breast enlargement regressed rapidly and disappeared after stopping treatment. During treatment all patients were found to have normal concentrations of plasma testosterone and oestradiol, and serum prolactin was normal in the two patients measured. Excision biopsy of the subareolar tissue in one patient revealed histology typical of the florid stage of gynaecomastia. Blockade of androgen-responsive receptors receptors in the target organ appears to be the most likely mechanism involved.
R W Spence, and
L R Celestin
August 1978,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
R W Spence, and
L R Celestin
February 1994,
BMJ (Clinical research ed.),
R W Spence, and
L R Celestin
April 1988,
British medical journal (Clinical research ed.),
R W Spence, and
L R Celestin
January 1999,
International journal of STD & AIDS,
R W Spence, and
L R Celestin
February 1989,
The British journal of dermatology,
R W Spence, and
L R Celestin
June 1987,
The Journal of the Association of Physicians of India,
R W Spence, and
L R Celestin
October 2002,
International journal of andrology,
R W Spence, and
L R Celestin
September 1972,
Proceedings of the Royal Society of Medicine,
R W Spence, and
L R Celestin
September 1967,
The Medical journal of Australia,
