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Synthesis of isoleucine-5-tyrosine-8-angiotensin II and isoleucine-5-hydroxyproline-7-angiotensin II. 1966

K M Sivanandaiah, and R R Smeby, and F M Bumpus

UI MeSH Term Description Entries
D007532 Isoleucine An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels. Alloisoleucine,Isoleucine, L-Isomer,L-Isoleucine,Isoleucine, L Isomer,L-Isomer Isoleucine
D010455 Peptides Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are considered to be larger versions of peptides that can form into complex structures such as ENZYMES and RECEPTORS. Peptide,Polypeptide,Polypeptides
D002625 Chemistry, Organic The study of the structure, preparation, properties, and reactions of carbon compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed) Organic Chemistry
D006909 Hydroxyproline A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation. Oxyproline,4-Hydroxyproline,cis-4-Hydroxyproline,4 Hydroxyproline,cis 4 Hydroxyproline
D000804 Angiotensin II An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. Angiotensin II, Ile(5)-,Angiotensin II, Val(5)-,5-L-Isoleucine Angiotensin II,ANG-(1-8)Octapeptide,Angiotensin II, Isoleucine(5)-,Angiotensin II, Valine(5)-,Angiotensin-(1-8) Octapeptide,Isoleucine(5)-Angiotensin,Isoleucyl(5)-Angiotensin II,Valyl(5)-Angiotensin II,5 L Isoleucine Angiotensin II,Angiotensin II, 5-L-Isoleucine
D014443 Tyrosine A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. L-Tyrosine,Tyrosine, L-isomer,para-Tyrosine,L Tyrosine,Tyrosine, L isomer,para Tyrosine
D055601 Organic Chemistry Phenomena The conformation, properties, reaction processes, and the properties of the reactions of organic carbon compounds. Organic Chemistry Concepts,Organic Chemistry Processes,Organic Chemistry Phenomenon,Organic Chemistry Process,Chemistry Process, Organic,Chemistry Processes, Organic,Concept, Organic Chemistry,Concepts, Organic Chemistry,Organic Chemistry Concept,Phenomena, Organic Chemistry,Phenomenon, Organic Chemistry,Process, Organic Chemistry,Processes, Organic Chemistry

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K M Sivanandaiah, and R R Smeby, and F M Bumpus
Synthesis of [5-isoleucine, 8-alanine]-angiotensin II by the solution method synthesis and the solid-phase method synthesis.
November 1967, Biochemistry,
K M Sivanandaiah, and R R Smeby, and F M Bumpus
Synthesis of analogs of (8-isoleucine)angiotensin II with variations in position 1.
April 1974, Journal of medicinal chemistry,
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Solid-phase synthesis of (3-proline,8-isoleucine)-,(1-sarcosine,3-proline,8-isoleucine)-, and (4-phenylalanine,8-isoleucine)angiotensin II as the antagonists of the parent hormone.
October 1973, Journal of medicinal chemistry,
K M Sivanandaiah, and R R Smeby, and F M Bumpus
Solid-phase synthesis of (6-arginine)-, (4-histidine, 6-tyrosine)-, and (8-isoleucine)angiotensins II.
June 1972, Journal of medicinal chemistry,
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Solid-phase peptide synthesis of [L-alanine 3-L-isoleucine 5]-angiotensin II.
March 1967, Biochemistry,
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Synthesis and pharmacological properties of [5-isoleucine]-, [8-isoleucine]-, and [5,8-diisoleucine]bradykinin.
March 1979, Journal of medicinal chemistry,
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[Clinical application of angiotensin II analogue (1-sarcosine, 8-isoleucine-angiotensin II) (author's transl)].
June 1974, Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
K M Sivanandaiah, and R R Smeby, and F M Bumpus
Antagonism of peripheral and central effects of angiotensin II by (1-sarcosine, 8-isoleucine)angiotensin II.
April 1973, The Journal of pharmacology and experimental therapeutics,
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[Effects of angiotensin II analogue (1-sarcosine, 8-isoleucine-angiotensin II) in various types of hypertension].
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