The aging human cerebral cortex: a stereological characterization of changes in the capillary net. 1979

O Hunziker, and S Abdel'Al, and U Schulz

Capillaries in the cerebral cortex of six age groups, ranging between 19 and 94 years (= 34 human brains) were stereologically investigated. Capillary parameters such as diameter, volume fraction, specific surface area, mean intercapillary distances and total length per unit cortex volume in patients older than 75 years were similar to those in young ones, 19 to 44 years old. Aged subjects between 64 and 74 years revealed increased capillary diameter, volume and total length per unit cortex volume, as well as decreased specific surface area. Frequency distributions in the same age indicate a real increase of capillary diameter and volume, as also an increase of these parameters on the level of blood vessels with diamteres greater than 8 micrometer, probably arterioles. The results of this study argue against the wide-spread assumption of a decreased blood supply in the cerebral cortex during old age. On the contrary, the capillary net is able to respond to changed metabolism and blood pressure.

UI MeSH Term Description Entries
D008297 Male Males
D008722 Methods A series of steps taken in order to conduct research. Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002196 Capillaries The minute vessels that connect arterioles and venules. Capillary Beds,Sinusoidal Beds,Sinusoids,Bed, Sinusoidal,Beds, Sinusoidal,Capillary,Capillary Bed,Sinusoid,Sinusoidal Bed
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging

Related Publications

O Hunziker, and S Abdel'Al, and U Schulz
January 1980, Mechanisms of ageing and development,
O Hunziker, and S Abdel'Al, and U Schulz
September 2003, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology,
O Hunziker, and S Abdel'Al, and U Schulz
April 1955, The Journal of comparative neurology,
O Hunziker, and S Abdel'Al, and U Schulz
January 2014, Frontiers in human neuroscience,
O Hunziker, and S Abdel'Al, and U Schulz
January 2002, Progress in brain research,
O Hunziker, and S Abdel'Al, and U Schulz
November 2003, The Journal of comparative neurology,
O Hunziker, and S Abdel'Al, and U Schulz
September 2016, Brain structure & function,
O Hunziker, and S Abdel'Al, and U Schulz
January 1979, Acta anatomica,
O Hunziker, and S Abdel'Al, and U Schulz
January 1978, Verhandlungen der Anatomischen Gesellschaft,
Copied contents to your clipboard!