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Limitation of the inflammatory cascade has been demonstrated in man by an inhibitor(s) of the prostaglandin system and by inhibitor(s) for chemotaxis of leukocytes. Other factors may exist in vivo that inhibit other inflammatory sequences. In this report, homogenates from human skin interfered with 2 standard assays of lymphocyte function, mitogen-induced transformation and cytotoxicity while homogenates of human placenta did not. Differential centrifugation studies located inhibitory factor(s) primarily in the nuclear fractions. Therefore, reversible transitory depressions of the cell-mediated immune response that are observed concomitantly with chronic dermatoses may reflect release of inhibitory material dermatitic skin in vivo.
C McKinney, and
A J Rzepiela, and
N S Penneys
March 1976,
Journal of immunology (Baltimore, Md. : 1950),
C McKinney, and
A J Rzepiela, and
N S Penneys
October 1977,
Canadian journal of microbiology,
C McKinney, and
A J Rzepiela, and
N S Penneys
August 1976,
Nature,
C McKinney, and
A J Rzepiela, and
N S Penneys
August 1983,
Journal of immunology (Baltimore, Md. : 1950),
C McKinney, and
A J Rzepiela, and
N S Penneys
January 1982,
International archives of allergy and applied immunology,
C McKinney, and
A J Rzepiela, and
N S Penneys
February 1974,
European journal of immunology,
C McKinney, and
A J Rzepiela, and
N S Penneys
November 1979,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
C McKinney, and
A J Rzepiela, and
N S Penneys
March 1979,
Clinical and experimental immunology,
C McKinney, and
A J Rzepiela, and
N S Penneys
December 1975,
Experimental cell research,
C McKinney, and
A J Rzepiela, and
N S Penneys
January 1981,
Experimental cell biology,
