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Glucagon immunoreactivity (IRG) was measured in plasma of 8 duodenopancreatectomized patients with antiserum 30-K. Arginine infusions failed to raise plasma IRG, whereas in control subjects IRG rose 3-fold. Column chromatography revealed that the basal IRG measured in these plasmas was not due to glucagon (molecular weight 3485) but to other plasma factors, mainly of high molecular weight. This suggests that diabetes mellitus does not require the presence of glucagon to produce the clinical picture, as suggested by other authors. Plasma levels of the amino acids alanine, serine, ornithine, and arginine were significantly (p less than 0.05) elevated, the former two being gluconeogenic substrates and the latter two constituents of the urea cycle. This amino acid abnormality may be a consequence of glucagon deficiency.
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
April 1983,
European journal of clinical investigation,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
January 1976,
Acta chirurgica Scandinavica,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
August 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
May 1976,
The Journal of clinical endocrinology and metabolism,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
September 1986,
British poultry science,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
December 1974,
The Journal of clinical endocrinology and metabolism,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
April 2024,
Clinical and experimental rheumatology,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
January 1980,
Kardiologia polska,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
April 1969,
Metabolism: clinical and experimental,
W A Muller, and
M Berger, and
P Suter, and
H J Cüppers, and
F H Schmidt, and
T Wyss, and
J P Assal, and
E Loizeau
September 1970,
Diabetes,
