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Rats fed a diet deficient in essential fatty acids have a low level of serum very low density lipoproteins (VLDL). It was found that after intraperitoneal injection of heparin, deficient rats had a higher level of lipoprotein lipase activity in their plasma than did normal rats. VLDL isolated from serum of normal and deficient rats were compared as substrates for postheparin lipase of rat plasma. There was no significant difference in V(max) between the two preparations of lipoproteins, but the apparent K(m) for lipoproteins from deficient animals was significantly less than that for normal animals. These observations suggest that the low concentration of VLDL in deficient rats may be explained (a) by an increased activity of lipoprotein lipase in the tissues of these animals and (b) by the VLDL of deficient rats being more rapidly hydrolyzed at low concentrations by lipoprotein lipase than VLDL from normal rats.
G G De Pury, and
F D Collins
December 1972,
The Japanese journal of dermatology. Ser. B,
G G De Pury, and
F D Collins
December 2008,
Prostaglandins, leukotrienes, and essential fatty acids,
G G De Pury, and
F D Collins
September 1979,
FEBS letters,
G G De Pury, and
F D Collins
March 1999,
The Journal of nutritional biochemistry,
G G De Pury, and
F D Collins
December 1991,
Clinica chimica acta; international journal of clinical chemistry,
G G De Pury, and
F D Collins
July 2005,
Atherosclerosis,
G G De Pury, and
F D Collins
May 2006,
Future cardiology,
G G De Pury, and
F D Collins
March 1978,
Biochemical and biophysical research communications,
G G De Pury, and
F D Collins
July 1996,
The Journal of biological chemistry,
G G De Pury, and
F D Collins
August 1978,
Experientia,
