-transparent.png){kind=logo}
Parathyroid hormone increased basal adenyl cyclase activity and that increase was inhibited by prostaglandin E(1) (PGE(1)). Tissue cyclic 3',5'-adenosine monophosphate (cyclic AMP) concentrations were increased by parathyroid hormone and that increase was likewise inhibited by PGE(1). Both parathyroid hormone and dibutyryl cyclic AMP increased (32)P incorporation into renal cortical phospholipids. PGE(1) diminished the effect of parathyroid hormone but not dibutyryl cyclic AMP to influence that parameter. PGE(1) likewise modulated the effect of parathyroid hormone but not dibutyryl cyclic AMP to decrease fractional phosphate reabsorption by the renal tubule. It is suggested that PGE(1) inhibits the effect of parathyroid hormone by decreasing its effect on adenyl cyclase. Such interaction may be important in modulating the intracellular action of parathyroid hormone on kidney cortex.
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
March 1974,
The Journal of clinical investigation,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
January 1981,
Annals of the New York Academy of Sciences,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
February 1973,
The Journal of clinical investigation,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
May 1972,
Archives internationales de pharmacodynamie et de therapie,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
October 1984,
Kidney international,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
August 1996,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
November 1976,
The American journal of physiology,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
January 1992,
Journal of endocrinological investigation,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
October 1982,
Metabolism: clinical and experimental,
N P Beck, and
F R DeRubertis, and
M F Michelis, and
R D Fusco, and
J B Field, and
B B Davis
January 1989,
Mineral and electrolyte metabolism,
