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The two steroid components of Alfathesin, alfaxolone and alfadolone acetate, have been tested for porphyrin-inducing activity in chick embryo liver cell culture and for hepatic ALA-synthetase-inducing activity in the 17-day-old chick embryo. In cell culture alfoxolone was shown to have potency comparable to that of thiopental, while alfadolone acetate had low potency. In the 17-day-old chick embryo alfaxolone has a third the potency of thiopental; alfadolone acetate showed low potency. The authors conclude that an induction dose of Alfathesin would be less likely than a comparable dose of thiopental to increase ALA-synthetase activity in a patient with hereditary hepatic porphyria.
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
August 1980,
Canadian journal of physiology and pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
January 1978,
Biochemical pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
June 1983,
Canadian journal of physiology and pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
August 1977,
Science (New York, N.Y.),
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
September 1981,
Molecular pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
July 1981,
Molecular pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
March 1986,
FEBS letters,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
January 1972,
Biochemical pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
March 1976,
Biochemical pharmacology,
P W Fischer, and
A Ferizovic, and
I R Neilson, and
G S Marks
July 1978,
Molecular pharmacology,
