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SQ 20881, an angiotensin-converting enzyme inhibitor, was given to 12 patients with renovascular hypertension and to 1 patient with unilateral parenchymatous renal disease in order to evaluate the role of renin-angiotensin systems in their hypertension. Plasma renin activity (PRA) and aldosterone were assayed in systemic blood before and after the injection of SQ 20881. In 5 patients PRA was also measured separately in each renal vein. Blood pressure decreased, PRA increased, and aldosterone level decreased in the 12 renin-dependent patients. When PRA was sampled separately from each renal vein, the increase was larger on the side of the affected kidney. Four patients with a positive test underwent corrective surgery, and in all blood pressure became normal. SQ 20881 is a useful agent in evaluating the contribution of renin in patients with hypertension.
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
January 1982,
Angiology,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
November 1979,
The American journal of medicine,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
August 1977,
British journal of pharmacology,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
January 1986,
American journal of nephrology,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
July 1980,
The Tohoku journal of experimental medicine,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
January 1980,
Doklady Akademii nauk SSSR,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
January 1992,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
June 1978,
Journal of neurochemistry,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
September 1977,
Circulation research,
T Rosenthal, and
E Kissin, and
E T Jacob, and
N Stern, and
Y Levi, and
R Adar
August 1974,
Lancet (London, England),
