-transparent.png){kind=logo}
The 1alpha-hydroxy derivative of vitamin D(3) has been chemically synthesized and tested for its biological activity. This analog has comparable biological activity on a weight basis to 1,25-dihydroxyvitamin D(3) in the stimulation of intestinal calcium transport and bone calcium mobilization in normnal and anephric rats. Because the 1alpha-hydroxy derivative is synthesized from cholesterol, it is easier and less expensive to prepare than 1alpha,25-dihydroxy derivative, making it attractive as a drug in the treatment of renal osteodystrophy and hypopara-thyroidism.
Related Publications
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
March 2007,
The Journal of pharmacology and experimental therapeutics,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
July 1975,
Biochemical and biophysical research communications,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
June 1978,
Biochemistry,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
November 2011,
Calcified tissue international,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
July 2010,
The Journal of clinical endocrinology and metabolism,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
December 1996,
Journal of cellular biochemistry,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
June 2002,
Bioorganic & medicinal chemistry letters,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
June 2002,
Bioorganic & medicinal chemistry letters,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
August 2001,
American journal of physiology. Endocrinology and metabolism,
M F Holick, and
E J Semmler, and
H K Schnoes, and
H F DeLuca
July 2001,
Steroids,
