Biomaterial Database

Localized herpes simplex infections in atopic dermatitis. 1979

J J Leyden, and D A Baker

Herpes simplex infections, localized to areas of atopic dermatitis, were documented in ten children. The typical clinical picture consisted of low-grade fever and exacerbation of the eczema with discrete vesicles localized to affected skin, followed by punched-out ulcerations. Recurrent attacks were observed in seven cases and coincided with active attacks of herpes labialis in other family members or close friends, suggesting reinfection as the source. In no patient did a disseminated Kaposi's varicelliform type of eruption develop. Viral cultures in 30 additional patients with acute flares of atopic dermatitis without vesicles or ulcerations failed to disclose any herpes simplex.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003876	Dermatitis, Atopic	A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	Eczema, Atopic,Eczema, Infantile,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,Atopic Dermatitis,Atopic Eczema,Atopic Neurodermatitis,Disseminated Neurodermatitis,Infantile Eczema
D005260	Female		Females
D006561	Herpes Simplex	A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	Herpes Simplex Virus Infection
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man