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In an effort to clarify the basis for the reduced cyclic AMP response to catecholamines in leukocytes and lymphocytes from asthmatic donors the response of these cells to prostaglandins has been examined. Cells with an impaired beta adrenergic response had an essentially unaltered response to prostaglandin E(1) (PGE(1)) indicating the presence of selective beta adrenergic blockade. In contrast to what was observed with cells from asthmatic individuals, in normal control leukocytes with reduced catecholamine responsiveness PGE(1) responses were usually reduced as well, suggesting a different mechanism. The excellent cyclic AMP response to PGE(1) in cells from asthmatic donors would suggest that the defect in catecholamine responsiveness is at the level of the beta adrenergic receptor although a contributory role of altered substrate concentrations or increased phosphodiesterase activity is not formally excluded.
C W Parker, and
M L Baumann, and
M G Huber
January 1973,
The Journal of clinical investigation,
C W Parker, and
M L Baumann, and
M G Huber
February 1975,
Polskie Archiwum Medycyny Wewnetrznej,
C W Parker, and
M L Baumann, and
M G Huber
May 1977,
The Journal of investigative dermatology,
C W Parker, and
M L Baumann, and
M G Huber
January 1982,
Prostaglandins, leukotrienes, and medicine,
C W Parker, and
M L Baumann, and
M G Huber
September 1976,
Annals of allergy,
C W Parker, and
M L Baumann, and
M G Huber
October 1979,
Alergia,
C W Parker, and
M L Baumann, and
M G Huber
September 1981,
Molecular pharmacology,
C W Parker, and
M L Baumann, and
M G Huber
January 1970,
Advances in biochemical psychopharmacology,
C W Parker, and
M L Baumann, and
M G Huber
January 1978,
Terapevticheskii arkhiv,
C W Parker, and
M L Baumann, and
M G Huber
December 1979,
Digestive diseases and sciences,
