BIOMAT Database Logo BIOMAT Database Logo

Effects of diphenylhydantoin upon glucose-induced insulin secretion in three patients with insulinoma. 1974

F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D007328 Insulin A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1). Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007516 Adenoma, Islet Cell A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM. Islet Cell Tumor,Islet of Langerhans Tumor,Nesidioblastoma,Pancreatic Islet Cell Tumors,Island Cell Tumor,Adenomas, Islet Cell,Island Cell Tumors,Islet Cell Adenoma,Islet Cell Adenomas,Islet Cell Tumors,Langerhans Tumor Islet,Nesidioblastomas,Tumor Islet, Langerhans,Tumor, Island Cell,Tumor, Islet Cell,Tumors, Island Cell,Tumors, Islet Cell
D010190 Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA). Cancer of Pancreas,Pancreatic Cancer,Cancer of the Pancreas,Neoplasms, Pancreatic,Pancreas Cancer,Pancreas Neoplasms,Pancreatic Acinar Carcinoma,Pancreatic Carcinoma,Acinar Carcinoma, Pancreatic,Acinar Carcinomas, Pancreatic,Cancer, Pancreas,Cancer, Pancreatic,Cancers, Pancreas,Cancers, Pancreatic,Carcinoma, Pancreatic,Carcinoma, Pancreatic Acinar,Carcinomas, Pancreatic,Carcinomas, Pancreatic Acinar,Neoplasm, Pancreas,Neoplasm, Pancreatic,Neoplasms, Pancreas,Pancreas Cancers,Pancreas Neoplasm,Pancreatic Acinar Carcinomas,Pancreatic Cancers,Pancreatic Carcinomas,Pancreatic Neoplasm
D010672 Phenytoin An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D001786 Blood Glucose Glucose in blood. Blood Sugar,Glucose, Blood,Sugar, Blood
D003981 Diazoxide A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group. Hyperstat,Proglycem
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D004359 Drug Therapy, Combination Therapy with two or more separate preparations given for a combined effect. Combination Chemotherapy,Polychemotherapy,Chemotherapy, Combination,Combination Drug Therapy,Drug Polytherapy,Therapy, Combination Drug,Chemotherapies, Combination,Combination Chemotherapies,Combination Drug Therapies,Drug Polytherapies,Drug Therapies, Combination,Polychemotherapies,Polytherapies, Drug,Polytherapy, Drug,Therapies, Combination Drug
D005260 Female Females

Related Publications

F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Inverse relationship between glucose metabolism and glucose-induced insulin secretion in rat insulinoma cells.
January 1990, Hormone research,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Murine insulinoma cell line with normal glucose-regulated insulin secretion.
June 1993, Diabetes,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Effect of diphenylhydantoin on plasma-insulin in insulinoma.
March 1973, Lancet (London, England),
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
[Insulin secretion in obese patients treated with diphenylhydantoin (DPH)].
January 1978, Polski tygodnik lekarski (Warsaw, Poland : 1960),
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Glucose-induced insulin secretion in patients with parathyroid disorders.
September 1978, Clinical endocrinology,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Suppression of endogenous insulin secretion by exogenous insulin in patients with insulinoma.
January 2000, Clinical endocrinology,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Disordered glucose and insulin metabolism in patients with insulinoma.
May 1975, Archives of internal medicine,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Eicosapentaenoic acid (C20:5) augments glucose-induced insulin secretion from beta-TC3 insulinoma cells.
October 1996, Pancreas,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
Glucose- and phorbol ester-induced insulin secretion in human insulinoma cells--association with protein kinase C activation.
November 1998, Biochemistry and molecular biology international,
F D Hofeldt, and S E Dippe, and S R Levin, and J H Karam, and M R Blum, and P H Forsham
The stimulus-secretion coupling of glucose-induced insulin release: effect of aminooxyacetate upon nutrient-stimulated insulin secretion.
August 1982, Endocrinology,
Copied contents to your clipboard!