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[Histochemical diagnosis of Hirschsprung's disease]. 1979

Z Lukás, and J Ludvikovský

Examination of 65 rectal biopsies and 10 resections by the histochemical detection of cholinesterase leads to the following conclusions: 1. Density of the nerve fibers in lamina propria is irregular and the examination of the cholinesterase activity may lead to falsely negative results in aganglionosis. 2. Constant is, in aganglionosis, the finding of markedly increased reaction in the nerve fibers of the muscularis mucosae and submucosa. 3. Biopsy must, therefore, include even muscularis mucosae and the choice of the instrument for biopsy removal must meet this requirement.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D008531 Megacolon Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON. Megacolons
D009412 Nerve Fibers Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the CENTRAL NERVOUS SYSTEM. Cerebellar Mossy Fibers,Mossy Fibers, Cerebellar,Cerebellar Mossy Fiber,Mossy Fiber, Cerebellar,Nerve Fiber
D012007 Rectum The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL. Rectums
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002802 Cholinesterases Acylcholineacylhydrolase,Cholase,Cholinesterase
D004796 Clinical Enzyme Tests Analyses for a specific enzyme activity, or of the level of a specific enzyme that is used to assess health and disease risk, for early detection of disease or disease prediction, diagnosis, and change in disease status. Enzyme Tests, Clinical,Clinical Enzyme Test,Enzyme Test, Clinical,Test, Clinical Enzyme,Tests, Clinical Enzyme
D005260 Female Females

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