Changes in type of collagen during the development of human post-burn hypertrophic scars. 1979

T Hayakawa, and Y Hashimoto, and Y Myokei, and H Aoyama, and Y Izawa

Neutral-salt soluble collagen was relatively abundant in young post-burn hypertrophic scars. The content of insoluble collagen was fairly low in granulation tissues, whereas it gradually increased over 2 years and reached a significantly higher value than that in normal skins. Interrupted gel electrophoresis was carried out to estimate the relative proportions of type III and type I collagens in the pepsin digests of human normal skins and post-burn scars. Granulation tissues showed an abnormally higher ratio of type III to type I (0.37--0.72) than the mean value of normal skins (0.17 +/- 0.04 (S.D.)). The ratio gradually decreased to the normal range after 2 years or so.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D002056 Burns Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like. Burn
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D002921 Cicatrix The fibrous tissue that replaces normal tissue during the process of WOUND HEALING. Scars,Cicatrization,Scar,Scarring
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

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