Decreased cerebrospinal fluid concentration of free phenylacetic acid in depressive illness. 1979

M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen

Cerebrospinal fluid free phenylacetic acid concentration in a series of depressive patients was significantly lower than values in control subjects. This acid derives from phenylethylamine and the findings may reflect a decrease in its brain formation. Such a deficit may be related to other recent observations of a decrease in urinary output of the major metabolites of the "trace amines", octopamine and tyramine: phenylethylamine is thought to be the precursor of these "trace amines".

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010648 Phenylacetates Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID. Benzeneacetates,Benzeneacetic Acids,Phenylacetic Acids,Acids, Benzeneacetic,Acids, Phenylacetic
D003863 Depression Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. Depressive Symptoms,Emotional Depression,Depression, Emotional,Depressive Symptom,Symptom, Depressive
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012737 Sex Factors Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances. Factor, Sex,Factors, Sex,Sex Factor

Related Publications

M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
December 1983, Journal of chromatographic science,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
May 1995, Acta psychiatrica Scandinavica,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
May 1976, Research communications in chemical pathology and pharmacology,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
October 1986, Acta medica Okayama,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
June 1972, Lancet (London, England),
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
July 1992, Lancet (London, England),
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
January 1974, Advances in biochemical psychopharmacology,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
March 1970, Archives of general psychiatry,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
January 2015, Scientific reports,
M Sandler, and C R Ruthven, and B L Goodwin, and A Coppen
August 1988, Acta psychiatrica Scandinavica,
Copied contents to your clipboard!