BIOMAT Database Logo BIOMAT Database Logo

[Arterial scleroproteins in atherosclerosis and hypertension (experimental studies)]. 1979

Ts Iurukova, and P Georgiev

The authors examined neosynthesis of fiber proteins (scleroproteins) in the aorta of rats with genetic hypertonia and with experimental atherosclerosis after application of 3H-proline and 3H-lysine and subsequent determination of radioactivity of collagenous and elastic in the aortic wall. There was a great increase in incorporation a labelled precursors of collagen and elastin in the aorta of hypertonic and atherosclerotic animals in comparison with the control rats-a manifestation of increased "de novo" synthesis of fiber proteins in rats with these arterial diseases. Furthermore the increased collagenosis dominated over that of elastogenesis. The irregularity in the activation of biosynthesis of both sclero-proteins in rats with hypertonia and atherosclerosis caused remodeling of macromolecular structure of the aretrial wall with a predominance of collagen over the remaining components of the connective tissue matrix. The resulting fibrosis of the arterial wall favoured the fixation of hypertonia and progression of atherosclerosis.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D006977 Hypertension, Renal Persistent high BLOOD PRESSURE due to KIDNEY DISEASES, such as those involving the renal parenchyma, the renal vasculature, or tumors that secrete RENIN. Hypertensions, Renal,Renal Hypertension,Renal Hypertensions
D008239 Lysine An essential amino acid. It is often added to animal feed. Enisyl,L-Lysine,Lysine Acetate,Lysine Hydrochloride,Acetate, Lysine,L Lysine
D011392 Proline A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons. L-Proline,L Proline
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D003094 Collagen A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH). Avicon,Avitene,Collagen Felt,Collagen Fleece,Collagenfleece,Collastat,Dermodress,Microfibril Collagen Hemostat,Pangen,Zyderm,alpha-Collagen,Collagen Hemostat, Microfibril,alpha Collagen
D004549 Elastin alpha-Elastin,kappa-Elastin,alpha Elastin,kappa Elastin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001011 Aorta The main trunk of the systemic arteries. Aortas
D001161 Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries. Arterioscleroses

Related Publications

Ts Iurukova, and P Georgiev
Increased arterial and elastin biosynthesis in experimental atherosclerosis and hypertension.
January 1977, Comptes rendus de l'Academie Bulgare des sciences : sciences mathematiques et naturelles,
Ts Iurukova, and P Georgiev
[Arterial hypertension in atherosclerosis].
May 1958, La Presse medicale,
Ts Iurukova, and P Georgiev
[Experimental arterial atherosclerosis].
January 1959, Annales de la nutrition et de l'alimentation,
Ts Iurukova, and P Georgiev
[Experimental studies on the pathogenesis of arterial hypertension].
January 1961, Fiziolohichnyi zhurnal,
Ts Iurukova, and P Georgiev
[ATHEROSCLEROSIS AND ARTERIAL HYPERTENSION. RECIPROCAL RELATIONSHIP].
December 1963, La Semana medica,
Ts Iurukova, and P Georgiev
[Arterial hypertension, vascular remodelling and atherosclerosis].
January 1993, Journal des maladies vasculaires,
Ts Iurukova, and P Georgiev
Electrocardiography in experimental atherosclerosis and hypertension.
July 1957, American heart journal,
Ts Iurukova, and P Georgiev
Experimental hypertension and atherosclerosis. Effect of pulmonary hypertension on cholesterol atherosclerosis.
May 1961, Archives of pathology,
Ts Iurukova, and P Georgiev
Cardiac and arterial hypertrophy and atherosclerosis in hypertension.
June 1994, Hypertension (Dallas, Tex. : 1979),
Ts Iurukova, and P Georgiev
Magnesium in arterial thrombosis, ischaemia-reperfusion injury, and atherosclerosis--evidence from experimental studies.
March 2003, Danish medical bulletin,
Copied contents to your clipboard!