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The potential of lung tissue of adult male rats metabolize dihydrotestosterone (DHT) in vitro was examined. Within 3 min, a homogenate of 100 mg lung tissue, cleared of blood by perfusion before homogenization, metabolized 90% of the [3H]DHT substrate. Appoximately 80% of the DHT was converted to 5 alpha-androstan- alpha, 17 beta-diol. The amount of 5 alpha-androstan-3 alpha, 17 beta-diol formed during a 5-min incubation increased linearly, with substrate concentrations ranging from 3.3 x 10(-8) to 3 x 10(-6) M. Thus, the capacity of rat lung tissue to metabolize DHT in vitro and the rate of 3 alpha-reduction of DHT are sufficiently great to consider the possibility that lung may be responsible for the rapid clearance of DHT from the circulation in this species.
L W Kao, and
M J Crosswell, and
J Weisz
March 1985,
Life sciences,
L W Kao, and
M J Crosswell, and
J Weisz
June 1984,
Biochemical and biophysical research communications,
L W Kao, and
M J Crosswell, and
J Weisz
August 1979,
Biochimica et biophysica acta,
L W Kao, and
M J Crosswell, and
J Weisz
April 1985,
Life sciences,
L W Kao, and
M J Crosswell, and
J Weisz
January 1975,
Current topics in molecular endocrinology,
L W Kao, and
M J Crosswell, and
J Weisz
September 1979,
Journal of reproduction and fertility,
L W Kao, and
M J Crosswell, and
J Weisz
July 1982,
Experientia,
L W Kao, and
M J Crosswell, and
J Weisz
January 1987,
Australian journal of biological sciences,
L W Kao, and
M J Crosswell, and
J Weisz
February 1969,
The Journal of clinical investigation,
L W Kao, and
M J Crosswell, and
J Weisz
January 1983,
Andrologia,
