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A polyneuropathy affecting a large number of workers was recently observed at a plant producing plastic-coated and color-printed fabrics. Epidemiological data suggested strongly that methyl N-butyl ketone (MBK) was responsible for the outbreak. This hypothesis is now supported by the development of a peripheral neuropathy in chickens, rats, and cats exposed to MBK at atmospheric concentrations of 200 to 600 parts per million, 24 hours per day, 7 days per week. Although the animals were exposed continuously and the affected workers were exposed intermittently, the averages of the total number of hours of exposure for development of the peripheral neutropathy in the animals and workers were remarkably close.
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
May 1976,
Connecticut medicine,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
April 1976,
Archives of neurology,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
April 1975,
Archives of neurology,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
January 1968,
American Industrial Hygiene Association journal,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
June 1974,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
April 1975,
Archives of neurology,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
January 1975,
Clinical toxicology,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
May 1975,
Journal of occupational medicine. : official publication of the Industrial Medical Association,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
June 1975,
Archives of environmental health,
J R Mendell, and
K Saida, and
M F Ganansia, and
D B Jackson, and
H Weiss, and
R W Gardier, and
C Chrisman, and
N Allen, and
D Couri, and
J O'Neill, and
B Marks, and
L Hetland
May 1974,
The New England journal of medicine,
