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Following the well established prevention of chemical carcinogenesis by vitamin A in several species of laboratory animals, we performed in vitro studies with human diploid fibroblasts in culture. Vitamin A-palmitate, alltransretinoic acid and the analogue compound Ro 10-9359 were found to reduce the formation of active intermediates following the administration of G3H Benzo(a)pyrene to the cells. This effect which lead to a considerable decrease of alkylated DNA is not based on a direct inhibition of Benzpyrene metabolizing enzymes by the retinoids but by a preferential inhibition of the de novo synthesis of these enzymes. This caused the well known substrate mediated enzyme induction of benzpyrene metabolizing enzymes to cease. From our data we conclude that the mechanism of the cancer protective effect of vitamin A with respect to certain carcinogens is based on an inhibited activation of procarcinogens. This effect can also be expected in human tissues.
F V Kohl, and
H W Rüdiger
October 1974,
Rivista di patologia nervosa e mentale,
F V Kohl, and
H W Rüdiger
February 1982,
Nihon Jibiinkoka Gakkai kaiho,
F V Kohl, and
H W Rüdiger
January 1975,
Estomatologia e cultura,
F V Kohl, and
H W Rüdiger
September 1983,
Biochemical and biophysical research communications,
F V Kohl, and
H W Rüdiger
February 1981,
Horumon to rinsho. Clinical endocrinology,
F V Kohl, and
H W Rüdiger
February 1980,
Lijecnicki vjesnik,
F V Kohl, and
H W Rüdiger
October 1975,
Nihon Funin Gakkai zasshi,
F V Kohl, and
H W Rüdiger
April 1982,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
F V Kohl, and
H W Rüdiger
January 1980,
Archives francaises de pediatrie,
F V Kohl, and
H W Rüdiger
January 1981,
Annales d'endocrinologie,
