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The removal of serum from the medium of ovarian granulosa cells in exponential or confluent stages of growth results in a rapid and pronounced decrease in the rate of transport of the non-metabolizable amino acid, alpha-aminoisobutyric acid. This decrease is rapidly and completely reversed by the addition of serum. The decrease and its reversal are insensitive to inhibitors of RNA and protein syntheisis and are unaffected by a number of other metabolic inhibitors. The serum requirement cannot be replaced by peptide hormones known to stimulate cell division and secretion by these cells. These data are consistent with a model of post-translational control of AIB transport by a high-molecular-weight component of serum.
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
January 1969,
Biochimica et biophysica acta,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
February 1972,
Biochimica et biophysica acta,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
December 1982,
Neurochemical research,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
December 1970,
Biochimica et biophysica acta,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
June 1968,
The Journal of biological chemistry,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
September 1967,
American journal of obstetrics and gynecology,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
January 1990,
Life sciences,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
January 1975,
Bollettino della Societa italiana di biologia sperimentale,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
July 1977,
Archiv fur Gynakologie,
W R Allen, and
M Nilsen-Hamilton, and
R T Hamilton, and
D Gospodarowicz
February 1970,
Biochemical and biophysical research communications,
