BIOMAT Database Logo BIOMAT Database Logo

Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH. 1968

P L Gigon, and T E Gram, and J R Gillette

UI MeSH Term Description Entries
D007099 Imipramine The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group. Imidobenzyle,Imizin,4,4'-Methylenebis(3-hydroxy-2-naphthoic acid)-3-(10,11-dihydro-5H-dibenzo(b,f)azepin-5-yl)-N,N-dimethyl-1-propanamine (1:2),Imipramine Hydrochloride,Imipramine Monohydrochloride,Imipramine Pamoate,Janimine,Melipramine,Norchlorimipramine,Pryleugan,Tofranil
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008861 Microsomes Artifactual vesicles formed from the endoplasmic reticulum when cells are disrupted. They are isolated by differential centrifugation and are composed of three structural features: rough vesicles, smooth vesicles, and ribosomes. Numerous enzyme activities are associated with the microsomal fraction. (Glick, Glossary of Biochemistry and Molecular Biology, 1990; from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) Microsome
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D009249 NADP Nicotinamide adenine dinucleotide phosphate. A coenzyme composed of ribosylnicotinamide 5'-phosphate (NMN) coupled by pyrophosphate linkage to the 5'-phosphate adenosine 2',5'-bisphosphate. It serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). (Dorland, 27th ed) Coenzyme II,Nicotinamide-Adenine Dinucleotide Phosphate,Triphosphopyridine Nucleotide,NADPH,Dinucleotide Phosphate, Nicotinamide-Adenine,Nicotinamide Adenine Dinucleotide Phosphate,Nucleotide, Triphosphopyridine,Phosphate, Nicotinamide-Adenine Dinucleotide
D009536 Niacinamide An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Nicotinamide,Vitamin B 3,Vitamin PP,3-Pyridinecarboxamide,Enduramide,Nicobion,Nicotinsäureamid Jenapharm,Papulex,Vitamin B3,3 Pyridinecarboxamide,B 3, Vitamin,B3, Vitamin,Jenapharm, Nicotinsäureamid
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D010860 Pigments, Biological Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms. Biological Pigments

Related Publications

P L Gigon, and T E Gram, and J R Gillette
Effect of substrates on hepatic microsomal cytochrome P-450.
November 1968, Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
P L Gigon, and T E Gram, and J R Gillette
Effect of caffeine on hepatic microsomal cytochrome P-450.
July 1970, Biochemical pharmacology,
P L Gigon, and T E Gram, and J R Gillette
The effect of substrates and inhibitors of cytochrome P-450 on the NADPH inhibition of the ATP-dependent, hepatic, microsomal calcium pump.
December 1990, FEBS letters,
P L Gigon, and T E Gram, and J R Gillette
Cytochrome b5 reduction by NADPH-cytochrome P-450 reductase.
September 1979, The Journal of biological chemistry,
P L Gigon, and T E Gram, and J R Gillette
Spectral intermediates during the reduction of hepatic microsomal cytochrome P-450.
May 1976, Journal of biochemistry,
P L Gigon, and T E Gram, and J R Gillette
A heme model system for the reduction of substrates by microsomal cytochrome P 450.
February 1982, Biochemical and biophysical research communications,
P L Gigon, and T E Gram, and J R Gillette
The association between cytochrome P-450 and NADPH-cytochrome P-450 reductase in microsomal membrane.
June 1975, FEBS letters,
P L Gigon, and T E Gram, and J R Gillette
Effect of temperature on the relationship between hepatic microsomal cytochrome P-450 reduction and ethylmorphine demethylation.
January 1971, Pharmacology,
P L Gigon, and T E Gram, and J R Gillette
Metabolism of dichlorobiphenyls by hepatic microsomal cytochrome P-450.
March 1981, Biochemical pharmacology,
P L Gigon, and T E Gram, and J R Gillette
Metabolism of monochlorobiphenyls by hepatic microsomal cytochrome P-450.
March 1980, Biochemical pharmacology,
Copied contents to your clipboard!