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Serum neutralizing antibody to canine distemper virus (CDV) was measured in 142 patients with multiple sclerosis (MS), an equal number of age and sex-matched normal controls, and 75 patients with other neurological disorders. An elevated antibody titer was found in the MS population compared to controls. Measles-neutralizing antibody was also found to be elevated in 128 patients with MS. The mean ratio of measles to CDV antibody was similar in the control and MS groups, but a wide range of measles to CDV ratios was found in individual patients and controls. No significant correlation was found between IgG levels and neutralizing antibody titers in MS sera. While the increased titer of measles and CDV antibody may represent a non-specific immunological response, these findings are also consistent with the hypothesis that CDV or a closely related measles virus may stimulate the increased level of measles and CDV antibodies found in MS sera.
S D Cook, and
P C Dowling, and
W C Russell
November 1983,
Annals of neurology,
S D Cook, and
P C Dowling, and
W C Russell
August 1980,
Acta neurologica Scandinavica,
S D Cook, and
P C Dowling, and
W C Russell
June 1978,
Lancet (London, England),
S D Cook, and
P C Dowling, and
W C Russell
August 1997,
Neurology,
S D Cook, and
P C Dowling, and
W C Russell
May 1978,
Lancet (London, England),
S D Cook, and
P C Dowling, and
W C Russell
October 1982,
Journal of the neurological sciences,
S D Cook, and
P C Dowling, and
W C Russell
January 1984,
Archives of virology,
S D Cook, and
P C Dowling, and
W C Russell
January 1959,
Archiv fur die gesamte Virusforschung,
S D Cook, and
P C Dowling, and
W C Russell
October 1980,
Lancet (London, England),
S D Cook, and
P C Dowling, and
W C Russell
January 1960,
Acta pathologica et microbiologica Scandinavica,
